Journal of Oral Health and Community Dentistry

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VOLUME 15 , ISSUE 1 ( January-April, 2021 ) > List of Articles

RESEARCH ARTICLE

Correlation between CD4 Count and Dental Caries in HIV-seropositive Children Undergoing Antiretroviral Therapy

Monica Mohanram, Madan PD Kumar

Citation Information : Mohanram M, Kumar MP. Correlation between CD4 Count and Dental Caries in HIV-seropositive Children Undergoing Antiretroviral Therapy. J Oral Health Comm Dent 2021; 15 (1):20-23.

DOI: 10.5005/jp-journals-10062-0096

License: CC BY-NC 4.0

Published Online: 01-04-2021

Copyright Statement:  Copyright © 2021; The Author(s).


Abstract

Background: India has the third-largest HIV epidemic in the world. According to the UNAIDS Gap report 2016, 2.1 million people were living with HIV and approximately 43% of Indian adults with the virus have access to antiretroviral treatment. Even though antiretroviral therapy (ART) use has reduced the prevalence of oral manifestations, there is an increase in the prevalence of dental diseases, mainly due to the chronic influence of some factors involved in the process of HIV infection. Among them are the prolonged use of sugary products, changes in salivary flow, etc. The aim of the present study was to assess the association of CD4 count with dental caries in HIV-seropositive patients receiving ART. Methods: A descriptive study was conducted. Demographic details and recent CD4 counts were recorded. For dental caries, the decayed, missing, filled teeth (DMFT) index was used. Data were analyzed using SPSS version 20. Pearson correlation was used to correlate CD4 count with dental caries. Results: Caries showed a strong positive correlation of 1.0 but were not found to be statistically significant (p-value = 0.8). Conclusion: The study findings showed that there is a close relationship between oral health and general health in children living with HIV, and it highlights the significance of advocate policies on oral health among children living with HIV.


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  1. UNAIDS. 2019. AIDSinfo.unaids.org.
  2. Fevrier M, Dorgham K, Rebollo A. CD4+ T cell depletion in human immunodeficiency virus (HIV) infection: role of apoptosis. Viruses 2011;3:586–612. DOI: 10.3390/v3050586.
  3. Parmadiati AE, Ernawati DS, Soebadi B, et al. Correlation oral hairy leukoplakia and CD4+ counts in HIV/AIDS patients at Dr. Soetomo Hospital Surabaya, Indonesia 2014. J Int Dent Med Res 2017;10(1):162–165. DOI: 10.4034/pboci.2019.191.119
  4. Nugraha AP, Triyono EA, Prahasanti C, et al. The correlation of pathognomonic periodontal manifestation with CD4+ level in people live with human immunodeficiency virus/acquired immunodeficiency syndrome in a Tertiary Hospital, Surabaya, Indonesia. J Int Oral Health 2019;11(3):137–140. DOI: 10.4103/jioh.jioh_53_19.
  5. Nugraha AP, Ernawati DS, Parmadiati AE, et al. Prevalence of Candida species in oral candidiasis and correlation with CD4+ counts in HIV/AIDS patients at Surabaya, Indonesia. J Int Dent Med Res 2018;11(1):81–85. DOI: 10.1111/j.1600-0714.1998.tb02082.x
  6. Nugraha AP, Ernawati DS, Parmadiati AE, et al. Study of drug utilization within an anti-fungal therapy for HIV/AIDS patients presenting oral candidiasis at UPIPI RSUD, Dr. Soetomo Hospital, Surabaya. J Int Dent Med Res 2018;11(1):131–134. DOI: 10.18203/2319-2003.ijbcp20173742
  7. Liu G, Saxena D, Chen Z, et al. HIV infection affects Streptococcus mutans levels, but not genotypes. J Dent Res 2012;91(9):834–840. DOI: 10.1177/0022034512454298.
  8. Madigan A, Murray P, Houpt M, et al. Caries experience and cariogenic markers in HIV-positive children and their siblings. Am Acad Pediatr Dent 1996;18:129–136. DOI: 10.1007/978-3-662-47450-1_1
  9. Damle SG, Jetpurwala AK, Saini S, et al. Evaluation of oral health status as an indicator of disease progression in HIV positive children. Pesqui Bras Odontopediatria Clin Integr 2010;10:151–156. DOI: 10.21101/cejph.a5079
  10. Merchant RH, Oswal JS, Bhagwat RV, et al. Clinical profile of HIV infection. Indian Paediatr 2001;38:239–246. DOI: 10.7439/ijbr
  11. Arpadi SM. Growth failure in children with HIV infection. J Acquir Immune Defic Syndr 2000;25:37–42. DOI: 10.1097/00042560-200010001-00006.
  12. Fernandes A, Cherubini K, Veeck EB, et al. Radiographic evaluation of dental anomalies in number, shape, size, position and structure in HIV-infected children. Rev ABO Nacional 2002;10(2):93–97. DOI: 10.5603/fm.a2017.0087
  13. Mehta A. Trends in dental caries in Indian children for the past 25 years. Indian J Dent Res 2018;29:323–328. DOI: 10.4103/ijdr.IJDR_615_17.
  14. Tehjashwini E, Kumar VD, Sushmita S, et al. A study on dental caries status among 5-18 years HIV and healthy children - a comparative study. IOSR J Dent Med Sci 2019;17(1):1–6. DOI: 10.9790/0853-1701130106.
  15. Sahana S, Krishnappa S, Krishnappa V. Low prevalence of dental caries in children with perinatal HIV infection. J Oral Maxillofac Pathol 2013;17(2):212–216. DOI: 10.4103/0973-029X.119742.
  16. Cavasin Filho JC, Giovani EM. Xerostomy, dental caries and periodontal disease in HIV+ patients. Braz J Infect Dis 2009;13(1):13–17. DOI: 10.1590/s1413-86702009000100005.
  17. Nittayananta W, Talungchit S, Jaruratanasirikul S, et al. Effects of longterm use of HAART on oral health status of HIV-infected subjects. J Oral Pathol Med 2010;39(5):397–406. DOI: 10.1111/j.1600-0714.2009.00875.x.
  18. Kalanzi D, Mayanja-Kizza H, Nakanjako D, et al. Extensive dental caries in a HIV positive adult patient on ART: case report and literature review. BMC Oral Health 2018;18(1):205. DOI: 10.1186/s12903-018-0675-3.
  19. Rwenyonyi CM, Birkeland JM, Haugejorden O, et al. Dental caries among 10 – 14-year- old children in Ugandan rural areas with 0,5 and 2.5 mg fluoride per liter in drinking water. Clin Oral Invest 2001;5:45–50. DOI: 10.1007/pl00010681.
  20. Baccaglini L, Atkinson JC, Patton LL, et al. Management of oral lesions in HIV-positive patients. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2007;103(suppl):S50.e1–S50.23. DOI: 10.1016/j.tripleo.2006.11.002.
  21. Rezaei-Soufi L, Davoodi P, Abdolsamadi HR, et al. Dental caries prevalence in human immunodeficiency virus infected patients receiving highly active anti-retroviral therapy in Kermanshah, Iran. Cell J 2014;16(1):73–78. DOI: 10.30476/dentjods.2019.44929
  22. Beena JP. Prevalence of dental caries and its correlation with the immunologic profile in HIV-Infected children on antiretroviral therapy. Eur J Paediatr Dent 2011;12(2):87–90. DOI: 10.4103/2F0973-029X.119742
  23. Obileye MF, Agbelusi GA, Orenuga OO, et al. Dental caries status of HIV infected children in Nigeria. Nig Q J Hosp Med 2009;19(4):210–213. DOI: 10.4314/nqjhm.v19i4.54530.
  24. Hicks MJ, Flaitz CM, Carter AB, et al. Dental caries in HIV-infected children: a longitudinal study. Pediatr Dent 2000;22(5):359–364. DOI: 10.17796/jcpd.38.1.62l1q94650j5l815
  25. Li X, Kolltveit KM, Tronstad L, et al. Systemic diseases caused by oral infection. Clin Microbiol Rev 2000;13:547–558. DOI: 10.1128/cmr.13.4.547-558.2000.
  26. Imai K, Victoriano AF, Ochiai K, et al. Microbial interaction of periodontopathic bacterium Porphyromonas gingivalis and HIV-possible causal link of periodontal diseases to AIDS progression. Curr HIV Res 2012;10:238–244. DOI: 10.2174/157016212800618183.
  27. Imai K, Ochiai, K. Role of histone modification on transcriptional regulation and HIV-1 gene expression: possible mechanisms of periodontal diseases in AIDS progression. J Oral Sci 2011;53:1–13. DOI: 10.2334/josnusd.53.1.
  28. Kikuchi K, Furukawa Y, Tuot S, et al. Association of oral health status with the CD4+ cell count in children living with HIV in Phnom Penh, Cambodia. Sci Rep 2019;9(1):14610. DOI: 10.1038/s41598-019-51077-0.
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