Journal of Oral Health and Community Dentistry

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VOLUME 7 , ISSUE 2 ( May-August, 2013 ) > List of Articles

REVIEW ARTICLE

Precancerous Oral Lesions: A Review

SK Panwar, A Bitharia

Citation Information : Panwar S, Bitharia A. Precancerous Oral Lesions: A Review. J Oral Health Comm Dent 2013; 7 (2):119-126.

DOI: 10.5005/johcd-7-2-119

License: NA

Published Online: 01-06-2014

Copyright Statement:  NA


Abstract

This article reviews the different types of oral lesions and factors associated with the development of premalignant (leukoplakia and erythroplakia) and actual cancerous lesions. Diagnostic tools and aids to diagnosis are discussed, as are treatment modalities. Early detections of these lesions could save lives.


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  1. Queries and responses from the Medical Committee of the Society for Investigating the Nature and Cure of Cancer. Edinburgh Med Surg J. 1806; 2:382–389.
  2. Oral and maxillofacial pathology. 2008 Philadelphia: W. B. Saunders, 3rd edition.
  3. Cancer following ichthyosis of the tongue. Trans Clin Soc Lond. 1870; 3:88–90.
  4. Oral Surg Oral Med Oral Pathol. 1990;70:597–599,.
  5. Histological Typing of Cancer and Precancer of the Oral Mucosa - World Health Organisation International. Histological Classification of Tumours. Berlin. Springer-Verlag 1997;21–31.
  6. An overview of the prevention of oral cancer and diagnostic markers of malignant change. Prevention Dent Update 2000; 27:95–99.
  7. Oral cancer. Mayo Clin Proc. 2007; 82(7):878–887.
  8. Demographics and occurrence of oral and pharyngeal cancers. The outcomes, the trends, the challenge. J Am Dent Assoc. Nov 2001;132 Suppl:7S–11S.
  9. SEER Cancer Statistics Review, 1975-2005, National Cancer Institute. Bethesda, MD, http://seer.cancer.gov/csr/1975_2005/, based on November 2007 SEER data submission, posted to the SEER web site, 2008 [database online]. 2008.
  10. Oral leukoplakia and malignant transformation. A follow-up study of 257 patients. Cancer. 1984;53(3):563–568.
  11. Observations on the clinical characteristics and natural history of oral leukoplakia. J Am Dent Assoc. 1968;76(4):772–777.
  12. Incidence rates for oral leukoplakia and lichen planus in a Japanese population. Journal of Oral Pathology and Medicine. 2005; 34(9):532–539.
  13. Natural history of potentially malignant oral lesions and conditions: an overview of the literature. J Oral Pathol Med. 2008; 37:1–10.
  14. The pathology of oral cancer and precancer revisited. Curr Diag Path. 2006; 12:11–21.
  15. Dysplasia scoring systems in oral precancers: predictive value, utility, weaknesses and scope for improvement. Proceedings, WHO Workshop on oral precancers, London, England, May, 2005.
  16. Malignant transformation in 1458 patients with potentially malignant oral mucosal disorders: a followup study based in a Taiwanese hospital. J Oral Pathol Med. 2007; 36:25–29.
  17. 1995. Erythroplakia: the dangerous red mucosa. Pract Periodontics Aesthet Dent. 1995;7(6):59–67; quiz 68.
  18. Common Oral Lesions: Part I. Superficial Mucosal Lesions. Am Fam Physician. 2007;75(4):501–506.
  19. , Pindborg, J.J., Smith, C.J. and van der Waal, I. Oral white lesions with special reference to precancerous and tobacco- related lesions: conclusions of an international symposium held in Uppsala, Sweden, May 18-21 1994. International Collaborative Group on Oral White Lesions. Journal of Oral Pathology and Medicine 1996; 25(2):49–54.
  20. International seminar on oral leukoplakia and associated lesions related to tobacco habits. Community Dentistry and Oral Epidemiology. 1984; 12:145–154.
  21. Definition of leukoplakia and related lesions: an aid to studies on oral precancer. Oral Surgery, Oral Medicine and Oral Pathology 1978;46(4):518–539
  22. Occurrence of leukoplakia and some other oral white lesions among 20,333 adult Swedish people. Community Dentistry and Oral Epidemiology 1987;15(1):46–51.
  23. HPV DNA in clinically different variants of oral leukoplakia and lichen planus. Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics 2004;98 (6):705–711.
  24. Clinical risk factors of oral\leukoplakia in a representative sample of the US population. Oral Oncology 2004;40 (2):158–163.
  25. J. Leukoplakia, lichen planus, and other oral keratoses in 23,616 white Americans over the age of 35 years. Oral Surgery, Oral Medicine and Oral Pathology 1986;61 (4):373–381.
  26. Epidemiological study of oral leukoplakia based on mass screening for oral mucosal diseases in a selected Japanese population. Community Dentistry and Oral Epidemiology, 1991; 19(3):160–163.
  27. Pooled estimate of world leukoplakia prevalence: a systematic review. Oral Oncology 2003;39:770–780.
  28. Incidence rates for oral leukoplakia and lichen planus in a Japanese population. J Oral Pathol Med 2005;34(9):532–539.
  29. Incidence rates of oral cancer and natural history of oral precancerous lesions in a 10-year follow-up study of Indian villagers. Community Dentistry and Oral Epidemiology 1980; 8(6):283–233.
  30. Malignant transformation in oral leukoplakia. Scandinavian Journal of Dental Research 1987; 95(6):449–455.
  31. Malignant transformation of oral leukoplakia: a follow-up study of a hospital-based population of 166 patients with oral leukoplakia from The Netherlands. Oral Oncology. 1998; 34(4):270–275.
  32. Is there a natural limit of the transformation rate of oral leukoplakia?. Oral Oncology. 2003; 39(5): 470–475.
  33. Lack of molecular markers to predict malignant potential of oral precancer. Journal of Pathology 2000;190(4): 407–409.
  34. Toluidine blue staining identifies high-risk primary oral premalignant lesions with poor outcome. Cancer Research 2005;65 (17):8017–8021.
  35. Predicting cancer development in oral leukoplakia: ten years of translational research. Clinical Cancer Research. 2000; 6(5):1702–1710.
  36. Loss of heterozygosity: a potential tool inmanagement of oral premalignant lesions?. Journal of Oral Pathology and Medicine. 2001;30(9):513–520.
  37. ABC of oral health. Oral cancer. BMJ. 2000;321(7253):97–100.
  38. 2005. Oral erythroplakia—a review. Oral Oncol. 2005;41(6):551–561.
  39. Oral lichen planus. Clin Dermatol. 2000;18:533–539.
  40. Oral lichen planus—a demographic study. Community Dent Oral Epidemiol. 1987; 15:52–56.
  41. Interventions for treating oral lichen planus. Cochrane Database Syst Rev. 1999;(2):CD001168.
  42. Oral submucous fibrosis. A review. Australian Dental Journal, 1996;41(5):294–299
  43. Oral submucous fibrosis: an unusual disease. JNJ Dental Association 1997; 68(2):17–19.
  44. Malignant transformation rate in oral submucous fibrosis over a 17-year period. Community Dental and Oral Epidemiology. 1985;13:340–341.
  45. Studies on oral submucous fibrosis: III. Epithelial changes. Oral Surgery, Oral Medicine, Oral Pathology 1976;41(2):203–21.
  46. The association between substance abuse and HIV infection among people visiting HIV counseling and testing centers in Addis Ababa, Ethiopia. EJHD 2005;19 (2).
  47. Oral Diseases 2002;8:40–43.
  48. Coexistence between oral lesions and opportunistic systemic diseases among HIV infected subjects in Thailand. J Oral Pathol Med 2002;31:163–168.
  49. Oral manifestations of HIV infection in relation to clinical and CD4 immunological status in northern and southern Thai patients. Oral diseases. 2004;10:138–144.
  50. Gender differences in HIV - related oral lesi in Oral Surg oral Med Oral Pathol Oral Radiol Endod 2001;92:478].
  51. Oral lichenoid lesions related to contact with dental materials: A literature review. Med Oral Patol Oral Cir Bucal. 2009;14(10):e514–520.
  52. Incidence of oral cancer in relation to nickel and arsenic concentrations in farm soils of patients' residential areas in Taiwan. BMC Public Health. 2010;10:67.
  53. Effect of screening on oral cancer mortality in Kerala, India: a cluster-randomised controlled trial. Lancet. 2005;365(9475):1927–1933.
  54. Diagnosis of oral squamous cell carcinoma and its precursor lesions. J Dtsch Dermatol Ges. 2007; 5(12):1095–1100.
  55. Analysis of oral lesion biopsies identified and evaluated by visual examination, chemiluminescence and toluidine blue. Oral Oncol. 2008;44(6):538–544.
  56. Adjunctive techniques for oral cancer examination and lesion diagnosis: a systematic review of the literature. J Am Dent Assoc. Jul 2008;139(7):896–905; quiz 993-994.
  57. Application of cytology and molecular biology in diagnosing premalignant or malignant oral lesions. Mol Cancer. Mar 23 2006;5:11.
  58. Understanding the biological basis of autofluorescence imaging for oral cancer detection: high-resolution fluorescence microscopy in viable tissue. Clin Cancer Res. 2008;14 (8):2396–2404.
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