Journal of Oral Health and Community Dentistry

Register      Login

VOLUME 4 , ISSUE Spl ( 2010 ) > List of Articles


Future of Periodontal Regeneration

Ranjan Malhotra, Anoop Kapoor, Vishakha Grover, Nitin Verma, Jasjit Kaur Sahota

Citation Information : Malhotra R, Kapoor A, Grover V, Verma N, Sahota JK. Future of Periodontal Regeneration. J Oral Health Comm Dent 2010; 4 (Spl):38-47.

DOI: 10.5005/johcd-4-Spl-38

License: CC BY-NC 3.0

Published Online: 01-01-2014

Copyright Statement:  Copyright © 2010; The Author(s).


The management of periodontal defects has been an ongoing challenge in clinical periodontics. In the recent past, attention has been focused more on regenerative and reconstructive therapies i.e. bone grafts, guided tissue regeneration, root conditioning, polypeptide growth factors, rather than on respective therapies. These therapeutic measures are shown to be limited in the predictability of healing and regenerative response in the modern clinical practice because oral environment presents several complicating factors that border regeneration. The 21st century appears to represent a time in history when there is a convergence between clinical dentistry and medicine, human genetics, developmental and molecular biology, biotechnology, bioengineering, and bioinformatics, resulting in the emergence of novel regenerative therapeutic approaches viz. tissue engineering, gene therapy and RNA interference. The focus of this review paper is to furnish and update the current knowledge of periodontal tissue engineering, gene therapy and RNA interference i.e. the future of periodontal regeneration.

PDF Share
  1. Future approaches in periodontal regeneration: Gene therapy, stem cells and RNA interference. Dent Clin N Am 54:141–155.
  2. Challenges and potential in tissue engineering. Periodontol 2000 2006;41:9–15.
  3. Pharmcogenomics: Translating functional genomics into rational therapeutics. Science 1999;286:487–491.
  4. Oral reports. The science 2000;(11-12):25–30.
  5. Systems biology and new technologies enable predictive and preventive medicine. Science 2004;306:640–643.
  6. Tissue engineering. Science 1993;260:920–926.
  7. Dissecting human diseases in post genomic era. Science 2001;291:1224–1229.
  8. Relationship of dental and oral pathology to systemic illness. J Am Med Assoc 84:1215–1217.
  9. The government's role in advancing regenerative medicine and tissue engineering science, safety and ethics. Periodontol 2000 2006:41:16–29.
  10. Central challenges facing the national clinical research enterrprise. J Am Med Assoc 2003;289:1278–1287.
  11. stem cells and future periodontal regeneration. Periodontol 2000 2009;51:239–257.
  12. molecular aspects of tissue engineering in the dental field. Periodontol 2000 2006;41:88–108.
  13. Tissue engineering: a new paradigm for regeneration based on molecular and biology. Periodontol 2000 2000;24:253–269.
  14. Bioengineered dental tissues grown in the rat jaw. J Dent Res 2008;87:745–750.
  15. enchancement of periodontal tissue regeneration by transplantation of bone marrow mesenchymal stem cells. J Periodontol 2004;75:1281–1287.
  16. Stem cell-based tissue engineering of murine teeth. J Dent Res 2004;83:518–522.
  17. Priniciples and applications of cell delivery systems for periodontal regeneration. Periodontol 2000 2006;41:123–135.
  18. Nuclear reprogramming in cells. Science 2008;322(5909):1811–1815.
  19. Tissue engineering - Current Challenges and expanding opportunities. Science 2002;295:1009–1014.
  20. Migration and division of progenitor cell populations in periodontal ligament after wounding. J Periodontal Res 1980;15(1):20–42.
  21. Participation of periodontal ligament cells with regeneration of alveolar bone. J Periodontol 2001;72(3):314–323.
  22. Role of fibroblast subpopulations in periodontal physiology and pathology. J Periodontal Res 1991;26(3 Pt 1):144–154.
  23. Putative stem cells in regenerating human periodontium. J Periodontal Res 2008;43(5):514–523.
  24. The impact of tissue engineering on dentistry. J Am Dent Assoc 2000;131:309–318.
  25. 1982-1992:a decade of technology development for guided tissue regeneration. J Periodontol 1993;64:1129–1137.
  26. The use of biologic mediators and tissue engineering in dentistry. Periodontol 2000 2009;50:127–153.
  27. Enhanced bone regeneration in beagle dogs with bovine bone mineral coated with synthetic oligopepetide. J Periodontol 2007;78:2150–2155.
  28. Stem cells. Setting standards for human embryonic stem cells. Science 2003;300:113–116.
  29. Gene therapeutics for periodontal regenerative medicine. Dent Clin N Am 2006;50:245–263.
  30. What does the future hold for periodontal tissue engineering? Int J Periodontics Restorative Dent 2002;22(1):6–7.
  31. Gene therapy of bone morphogenetic proteinfor periodontal tissue engineering. J Periodontol 2003;74(2):202–213.
  32. A review of new developments in tissue engineering therapy for periodontics. Dent Clin N Am 2006;50:265–276.
  33. Gene transfer and expression of platelet-derived growth factors modulate periodontal cellular activity. J Dent Res 2001;80:892–897.
  34. Effect of sustained gene delivery of platelet-derived growth factor or its antagonist (PDGF-1308) on tissue engineered cementum. J Periodontol 2004;75:429–440.
  35. Platelet-derived growth factor (PDGF) gene delivery for application in periodontal tissue engineering. J Periodontol 2001;72:815–823.
  36. Bone sialoprotein gene transfer to periodontal ligament cells may not be sufficient to promote mineralization in vitro or in vivo. J Periodontol 2006;77:1167–1173.
  37. Biological approaches to bone regeneration by gene therapy. J Dent Res 2005;84(12):1093–1103.
  38. Platelet-derived growth factor stimulates bone fill and rate of attachment level gain: results of a large multicenter randomized controlled trial. J Periodontol 2005;76(12):2205–2215.
PDF Share
PDF Share

© Jaypee Brothers Medical Publishers (P) LTD.