Journal of Oral Health and Community Dentistry

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VOLUME 4 , ISSUE Spl ( 2010 ) > List of Articles

REVIEW ARTICLE

Periodontal Vaccine: A New Paradigm for Prevention of Periodontal Diseases

Nitin Khuller

Citation Information : Khuller N. Periodontal Vaccine: A New Paradigm for Prevention of Periodontal Diseases. J Oral Health Comm Dent 2010; 4 (Spl):23-28.

DOI: 10.5005/johcd-4-Spl-23

License: CC BY-NC 3.0

Published Online: 01-01-2014

Copyright Statement:  Copyright © 2010; The Author(s).


Abstract

Vaccination is a process that induces specific immune resistance to a bacterial or viral infectious disease. Vaccines have prevented several infectious diseases for many years, and are still being investigated. In late eighteenth century, Edward Jenner developed and established the principle of vaccination using the cross protection conferred by cowpox virus, which is non pathogenic in humans.

Regarding a vaccine against the periodontal disease, the complexity of the periodontopathic bacteria might be a problem in determination of Antigens. Among some 300 species of bacteria involved in subgingival plaque, 5-7 species have been implicated in the etiology of periodontitis but one or two species; P.gingivalis or B. forsythus might play an important role as primary pathogens.

Vaccination accomplished can be active immunization, passive immunization or DNA vaccination, made from the antigenic epitopes in periodontopathic bacteria. In light of the increasing evidence that periodontitis significantly increases risk for potentially fatal diseases such as coronary heart disease, stroke and complications from diabetes mellitus a successful vaccine for periodontitis could have health benefits far exceeding the prevention of periodontitis.


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  1. Text book of Immunology, Fourth Edition, 1998.
  2. Assessment of risk for periodontal disease. II. Risk indicators for alveolar bone loss. J Periodontol 1995;66:23–29.
  3. Assessment of risk for periodontal disease. I. Risk indicators for attachment loss. J Periodontol 1994;65:260–267.
  4. Mucosal immunity and periodontitis: Mucosal vaccines. San Diego: Academic Press 1996;437–449.
  5. Immune responses and vaccination against periodontal infections. J Clin Periodontol 2005;32(Suppl 6):54–56.
  6. Modulation of colonization by black-pigmented Bacterial species in squirrel monkeys by immunization with Bacteroides gingivalis. Infect Immun 1989;57:2313–2317.
  7. Macaca Fascicularis as a model in which to assess the safety and efficacy of a vaccine for periodontitis. Oral Microbiol Immunol 1994;9:104–111.
  8. Periodontitis in man and other animals. Basel: Karger 1982.
  9. Microbiological and immunological aspects of experimental periodontal disease in rats: a review article. J Periodontol 1991;62:59–73.
  10. Porphyromonas gingiva/is virulence in mice: induction of immunity to bacterial components. Infect Immun 1992;60:1455–1464.
  11. Periodontal bone level and gingival proteinase activity in gnotobiotic rats immunized with Bacteroides gingiva/is. Oral Microbiol Immunol 1991;6:193–201.
  12. Influence of immunization 01}-Porphyromonas gingiva/is, colonization and invasion in the mouse chamber model. Infect Immun 1992;60:1447–1454.
  13. Protective efficacy of active and passive immunizations against experimental infection with Bacteroides gingiva/is in ligated hamsters. J Dent Res 1998;67:807–811.
  14. Immunization against Porphyromonas gingiva/ is inhibits progression of experimental periodontitis in nonhuman primates. Infect Immun 1994;62:1026–1031.
  15. Evaluation of cross-protection by immunization with an experimental trivalent companion animal periodontitis vaccine in the mouse periodontitis model. J Vet Dent 2008;25(1): 23–27.
  16. Vaccination and periodontitis: myth or reality. J Int Acad Periodontol 2000;2(2): 31–43.
  17. Infect Immun 1991;59:3351–3359.
  18. Bacteroides gingivalis. Bacteroides asaccharolyticus, and Bacteroides melaninogenicus subspecies: cell surface morphology and adherence to erythrocytes and human buccal epithelial cells. CUff Microbiol 1981;6:7–12.
  19. Inununization with Porphyromonas (Bactero. ides) gingivalis fimbriae against periodontal destruction. Infect Immun 1992;2926–2935.
  20. Characterization of a polysaccharide antigen from Bacteroides gingivalis. J Immunol 1989;143:3035–3042.
  21. An immune response directed to proteinase and adhesion functional epitopes protects against P. gingivalis-induced periodontal bone loss. J Immunol 2005;175(6):3980–3989.
  22. The role of antibodies to periodontal organisms. In: Genco RJ Parkh-ill R, Ed. Molecular basis for pathogenesis and molecular targeting in periodontal diseases. Buffalo: SUNY at Buffalo, Department of Oral Biology 1993:40.
  23. Tcell and B-cell epitope mapping and construction of peptide vaccines. In: Genco RJ, Hamada S, Lehner T, McGhee JR, Mergenhagen S, ed. Molecular pathogenesis of periodontal disease. Washington, DC: ASM Press, 1994;279–292.
  24. Porphyromonas gingivalis heat shock protein vaccine reduces the alveolar bone loss induced by multiple periodontopathogenic bacteria. J Periodontal Res 2006;41(1):10–14.
  25. Synthetic peptides analogous to the fimbrillin sequence inhibit adherence of Porphyromonas gingivalis. Infect Immun 1992;60:1662–1670.
  26. Bactericidal Activity of a Monoclonal Antibody Against Recombinant 40-kDa Outer Membrane Protein of P. gingivalis. J Periodontal 2000;71:368–375.
  27. Gene cloning of Porphyromonas gingivalis specific antigens recognized by serum of adult periodontitis patient. Int J Biochem 1992;24:945–950.
  28. Characterization of recombinant and native forms of a cell surface antigen of Porphyromonas (Bacteroides) gingivalis. Infect Immun 1993;61:3294–3303.
  29. Molecular cloning and sequence analysis of antigen gene tdp A of Treponema denticola. Infect Immun 1991;59:1941–1947.
  30. Molecular cloning and characterization of the genes encoding the immunore active major cell-surface proteins of Porphyromonas gingivalis. FEMS Microbiol Lett 1994;120:23–30.
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