Citation Information :
Mahale SA, Walvekar AK, Tiwari S, Patil RD, Harish S, Mehta A, Jadhav SS. Efficacy of Colloidal Nanosilver Tooth Gel in the Management of Orodental Conditions: A Prospective, Randomized, Triple Arm, Parallel, Double-blind Controlled Interventional Clinical Study. J Oral Health Comm Dent 2023; 17 (2):49-56.
Objective: Poor orodental health is a root cause of various oral conditions, viz., dental caries, periodontal diseases, malocclusion, orofacial anomalies, and many more that result in pain, suffering, and even disability. Around 3.5 billion population suffers from one or the other dental condition globally. Moreover, poor orodental health also contributes to many systemic diseases. The newer therapeutic agents are needed to prevent dental caries and plaque formation and thereby protect teeth from further damage. Colloidal Nanosilver (SilverSol®) Tooth Gel is a colloidal nanosilver preparation along with xylitol and peppermint oil with a unique biodisruptive nanotechnology having multidimensional activity due to its wound healing and antimicrobial properties.
Methodology: The present study was conducted on 120 patients suffering from different dental conditions to assess the efficacy of SilverSol® Tooth Gel.
Results: SilverSol® showed a significant effect in almost all the conditions monitored in the patients. There was a reduction in extrinsic tooth stains and pocket depth score in the mouth by 58.6 and 52.2% respectively. Breath malodor also showed improvement as the score reduced by 66%. Altogether, it contributed to the overall oral health improvement by 69%.
Conclusion: SilverSol® Tooth Gel is effective in several orodental conditions including periodontitis and gingivitis in comparison to chlorhexidine gel. Routine application of SilverSol® Tooth Gel will prevent these conditions and maintain the overall orodental health.
Sheiham A. Oral health, general health and quality of life. Bull World Health Organ 2005;83(9):641–720. PMID: 16211151.
El Tantawi M, AlAgl A. Disability and the impact of need for periodontal care on quality of life: a cross-sectional study. J Int Med Res 2017;45(6):1949–1960. DOI: 10.1177/0300060517715376.
Listl S, GallowayJ, Mossey PA, et al. Global economic impact of dental diseases. J Dent Res 2015;94(10):1355–1361. DOI: 10.1177/0022034515602879.
Williams RC. Periodontal diseases. New England J Med 1990;322: 373–382. DOI: 10.1056/NEJM199002083220606.
Kilian M. Systemic disease: manifestations of oral bacteria. In: JR MG, Michalek SM, Cassell GH (Eds) Dental microbiology. Philadelphia, PA: Harpers & Row, 1982, pp. 832–838.
Devaraj C, Eswar P. Reasons for use and non-use of dental services among people visiting a dental college hospital in India: a descriptive cross-sectional study. Eur J Dent 2012;6(4):422–427. PMID: 23077423.
Dunne SM, Gainsford ID, Wilson NH. Current materials and techniques for direct restorations in posterior teeth. Part 1: silver amalgam. Int Dent J 1997;47(3):123–136. DOI: 10.1002/j.1875-595x.1997.tb00777.x.
Noronha VT, Paula AJ, Durán G, et al. Silver nanoparticles in dentistry. Dent Mater 2017;33(10):1110–1126. DOI: 10.1016/j.dental.2017.07.002.
Marambio-Jones C, Hoek EMV. A review of the antibacterial effects of silver nanomaterials and potential implications for human health and the environment. J Nanopart Res 2010;12:1531–1551. DOI: 10.1007/s11051-010-9900-y
Abbaszadegan A, Nabavizadeh M, Gholami A, et al. Positively charged imidazolium-based ionic liquid-protected silver nanoparticles: a promising disinfectant in root canal treatment. Int Endod J 2015;48(8):790–800. DOI: 10.1111/iej.12377.
Wu D, Fan W, Kishen A, et al. Evaluation of the antibacterial efficacy of silver nanoparticles against Enterococcus faecalis biofilm. J Endod 2014;40(2):285–290. DOI: 10.1016/j.joen.2013.08.022.
Holladay RJ, Herbert C, Moeller WD.Apparatus and method for producing antimicrobial silver solution. US Patent Patent, US6743348B2 United States.
De Souza A Vora AH, Mehta AD, et al. SilverSol® a nano-silver preparation: a multidimensional approach to advanced wound healing. In: Kumar P, Kothari V (Eds.). Wound Healing Res: Curr Trends Future Directions, 2021, pp. 355–396.
Roy R, Hoover MR, Bhalla AS, et al. Ultradilute Ag-aquasols with extraordinary bactericidal properties: role of the system Ag–O–H2O. Mater Res Innov 2007;11(1):3–18. DOI: 10.1179/1433075 07X196167.
Revelli DA, Lydiksen CG, Smith JD, et al. A unique Silver Sol with broad antimicrobial properties. Antimicrobial 2011;3(11):5–16.
Pradeep AR, Kumari M, Priyanka N, et al. Efficacy of chlorhexidine, metronidazole and combination gel in the treatment of gingivitis--a randomized clinical trial. J Int Acad Periodontol 2012;14(4):91–96. PMID: 23210197.
Chow S, Shao J, Wang H. Sample Size Calculation in Clinical Research. Chapman & Hall/CRC Press, 2003.
ASTM. Manual on Sensory Testing Methods. STP 434. Philadelphia: American Society for Testing and Materials, 1968. pp. 1–77.
Rosenberg M, McCulloch CA. Measurement of oral malodor: current methods and future prospects. J Periodontol 1992;63(9):776–782. DOI: 10.19 02/jop.1922.214.171.1246.
Lobene RR. Effect of dentifrices on tooth stains with controlled brushing. J Amer Dent Assoc 1968;77:849–855. DOI: 10.14219 /jada.archive.1968.0298.
Kayser-Jones J, Bird WF, Paul SM,et al. An instrument to assess the oral health status of nursing home residents. Gerontol 1995;35(6): 814–824. DOI: 10.1093/geront/35.6.814.
Löe, Harald. The Gingival Index, the Plaque Index and the Retention Index Systems. J Periodontol 1967;38(6):610–616. DOI: 10.1902/jop.19126.96.36.1990.
Alexander JW. History of the medical use of silver. Surg Infect (Larchmt). 2009;10(3):289–292. DOI: 10.1089/sur.2008.9941.
Melaiye A, Youngs WJ. Silver and its application as an antimicrobial agent, Expert Opin Therap Patents 2005;15(2): 125–130. DOI: 10. 1517/135437188.8.131.52.
De Souza A, Mehta D, Leavitt RW. Bactericidal activity of combinations of Silver--Water Dispersion with 19 antibiotics against seven microbial strains. Curr Sci 2006;91(7): 926–929.
Monteiro DR, Gorup LF, Silva S, et al. Silver colloidal nanoparticles: antifungal effect against adhered cells and biofilms of Candida albicans and Candida glabrata. Biofouling 2011;27(7): 711–719. DOI: 10.1080/08927014.2011.599101.
Kuruwa M, Pathak H, Mehta A, et al. An open labeled multicentric pilot trial to study the safety and efficacy of colloidal nano silver skin cream in patients with various skin diseases. Biomed J Sci Tech Res 2022;46(1):37040–37048. DOI: 10.26717/BJSTR.2022.46.007290.
Tran PL, Luth K, Wang J, et al. Efficacy of a silver colloidal gel against selected oral bacteria in vitro. F1000Res. 2019;8:267. DOI: 10.12688/f1000research.17707.1.
Tran P, Kopel J, Luth K, et al. The in vitro efficacy of betadine antiseptic solution and colloidal silver gel combination in inhibiting the growth of bacterial biofilms. Am J Infect Control 2022;51(1):23–28. S0196-6553(22)00268-1. DOI: 10.1016/j.ajic.2022.04.002.
Acosta-Torres LS, Mendieta I, Nuñez-Anita RE, et al. Cytocompatible antifungal acrylic resin containing silver nanoparticles for dentures. Int J Nanomed 2012;7:4777–4786. DOI: 10.2147/IJN.S32391.
Rani S, Chandra RV, Reddy AA, et al. Evaluation of the antibacterial effect of silver nanoparticles on guided tissue regeneration membrane colonization--an in vitro study. J Int Acad Periodontol 2015;17(3):66–76. PMID: 26373223.
Yin IX, Zhang J, Zhao IS, et al. The antibacterial mechanism of silver nanoparticles and its application in dentistry. Int J Nanomed 2020; 15:2555–2562. DOI: 10.2147/IJN.S246764.
Stefano Sivolella, Edoardo Stellini, Giulia Brunello, et al. Silver nanoparticles in alveolar bone surgery devices. J Nanomater 2012;12(1):15. DOI: 10.1155/2012/975842.
Sakthi Devi R, Girigoswami A, Siddharth M, et al. Applications of gold and silver nanoparticles in theranostics. Appl Biochem Biotechnol 2022;194(9):4187–4219. DOI: 10.1007/s12010-022-03963-z.
Khubchandani M, Thosar NR, Dangore-Khasbage S, et al. Applications of silver nanoparticles in pediatric dentistry: an overview. Cureus 2022;14(7):e26956. DOI: 10.7759/cureus.26956.
Butrón Téllez Girón C, Hernández Sierra JF, DeAlba-Montero I, et al. Therapeutic use of silver nanoparticles in the prevention and arrest of dental caries. Bioinorg Chem Appl 2020;2020:8882930. DOI: 10.1155/2020/8882930.
Haugen HJ, Makhtari S, Ahmadi S, et al. The antibacterial and cytotoxic effects of silver nanoparticles coated titanium implants: a narrative review. Mater (Basel) 2022;15(14):5025. DOI: 10.3390/ma15145025.
Fernandez CC, Sokolonski AR, Fonseca MS, et al. Applications of silver nanoparticles in dentistry: advances and technological innovation. Int J Mol Sci 2021;22(5):2485. DOI: 10.3390/ijms22052485.