Citation Information :
Sri SM, Nimmy P. Effects of Chewing Gums Containing Xylitol and Sorbitol on Salivary Microflora, Plaque, and Gingiva: A Systematic Review. J Oral Health Comm Dent 2022; 16 (3):138-141.
Aim: This study is targeted to assess the effect of chewing gums containing xylitol and sorbitol on salivary microflora, plaque, and gingiva.
Materials and methods: The literature review was performed using PubMed, Cochrane Central Register of Controlled Trials (CENTRAL), Science Direct, Lilacs, Google Scholar, Gray Literature, and Ovid MEDLINE using MeSH Terms—Chewing gums, xylitol, and sorbitol. Among the total of 870 titles appearing from various sources, 746 records were screened, and 70 were related to the research. This review is described according to PRISMA guidelines for systematic review.
Results: Four randomized control trial articles were included, effects of xylitol and sorbitol chewing gums were compared. Among the four trials, three found statistically significant differences favoring the effects of chewing gums containing xylitol and sorbitol.
Conclusion: Thereby, we can conclude that xylitol- and sorbitol-containing chewing gums affect salivary microflora, plaque, and gingiva.
Clinical significance: Prevention of plaque and salivary microflora using xylitol and sorbitol.
Oza S, Patel K, Bhosale S, et al. To determine the effect of chewing gum containing xylitol and sorbitol on mutans streptococci and Lactobacilli count in saliva, plaque, and gingival health and to compare the efficacy of chewing gums. J Int Soc Prev Community Dent 2018;8(4):354–360. DOI: 10.4103/jispcd.JISPCD_54_18.
Shwetha R, Vivek S. Effect of dentifrices containing sorbitol, combination of xylitol and sorbitol on salivary Streptococcus mutans and Lactobacillus counts in 14–15-year-old children: A randomized trial. Int J Clin Trials 2017;4(4):184–190. DOI: 10.18203/2349-3259.ijct20174865.
Tuncer D, Önen A, Yazici AR. Effect of chewing gums with xylitol, sorbitol and xylitol–sorbitol on the remineralization and hardness of initial enamel lesions in situ. Dent Res J 2014;11(5):537–543. PMID: 25426142.
Holgerson PL, Sjöström I, Stecksén-Blicks C, et al. Dental plaque formation and salivary mutans streptococci in schoolchildren after use of xylitol-containing chewing gum. Int J Paediatr Dent 2007;17(2):79–85. DOI: 10.1111/j.1365-263X.2006.00808.x.
Milgrom P, Ly KA, Roberts MC, et al. Mutans streptococci dose response to xylitol chewing gum. J Dent Res 2006;85(2):177–181. DOI: 10.1177/154405910608500212.
Topitsoglou V, Birkhed D, Larsson LÅ, et al. Effect of chewing gums containing xylitol, sorbitol or a mixture of xylitol and sorbitol on plaque formation, pH changes and acid production in human dental plaque. Caries Res 1983;17(4):369–378. DOI: 10.1159/000260690.
Burt BA. The use of sorbitol-and xylitol-sweetened chewing gum in caries control. J Am Dent Assoc 2006;137(2):190–196. DOI: 10.14219/jada.archive.2006.0144.
Bretz WA, Rosa OP, Silva SM, et al. Compliance with xylitol and sorbitol chewing gum regimens in clinical trials. Suom Hammaslaakarilehti 2006;13(Suppl 1):25–27. PMID: 22241940.
Keukenmeester RS, Slot DE, Rosema NA, et al. Effects of sugar-free chewing gum sweetened with xylitol or maltitol on the development of gingivitis and plaque: A randomized clinical trial. Int J Dent Hygiene 2014;12(4):238–244. DOI: 10.1111/idh.12071.
Chavan S, Lakashminarayan N, Kemparaj U. Effect of chewing xylitol containing and herbal chewing gums on salivary mutans streptococcus count among school children. Int J Prev Med 2015;6:44. DOI: 10.4103/2008-7802.157543.
Rafeek R, Carrington CV, Gomez A, et al. Xylitol and sorbitol effects on the microbiome of saliva and plaque. J Oral Microbiol 2019;11(1):1536181. DOI: 10.1080/20002297.2018.1536181.
