Odontogenic myxoma is a benign, locally aggressive neoplasm that is known to have a high recurrence rate. Fibromyxoma is a variant of myxoma with a higher fibrous–myxoid tissue ratio. The peripheral type of odontogenic fibromyxoma still remains a diagnostic challenge, as very few cases are reported in the literature. One such case is reported here. A 54-year-old male patient reported to our OPD with a diffuse, slowly enlarging growth in the lower right side of the jaw without crossing the midline. Orthopantomogram was done that revealed generalized bone loss with cratering at the lesion site. Incisional biopsy was done along with immune histochemical evaluation for diagnosis confirmation. Surgical excision was done. No recurrence has been reported till now. These lesions clinically mimic any benign peripheral neoplasm. Hence, precise diagnosis is imperative before initiation of management protocols. Wide margin excision and rigid follow-up are recommended to minimize the chance of recurrence.
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